Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS

Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS

Abstract Mitochondrial injury in granulosa cells (GCs) is associated with the pathophysiological mechanism of polycystic ovary syndrome (PCOS). Melatonin reduces the mitochondrial injury by enhancing SIRT1 (NAD-dependent deacetylase sirtuin-1), while the mechanism remains unclear. Mitochondrial memb...

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Bibliographic Details
Main Authors: Bo Zheng, Junan Meng, Yuan Zhu, Min Ding, Yuting Zhang, Jianjun Zhou
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Ovarian Research
Subjects:
Melatonin
PCOS
Akt
SIRT1
mPTP
Online Access:https://doi.org/10.1186/s13048-021-00912-y

Internet

https://doi.org/10.1186/s13048-021-00912-y

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