The Histidine Ammonia Lyase of Trypanosoma cruzi Is Involved in Acidocalcisome Alkalinization and Is Essential for Survival under Starvation Conditions

The Histidine Ammonia Lyase of Trypanosoma cruzi Is Involved in Acidocalcisome Alkalinization and Is Essential for Survival under Starvation Conditions

ABSTRACT Trypanosoma cruzi, the agent of Chagas disease, accumulates polyphosphate (polyP) and Ca2+ inside acidocalcisomes. The alkalinization of this organelle stimulates polyP hydrolysis and Ca2+ release. Here, we report that histidine ammonia lyase (HAL), an enzyme that catalyzes histidine deamin...

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Bibliographic Details
Main Authors: Brian S. Mantilla, Cristina Azevedo, Paul W. Denny, Adolfo Saiardi, Roberto Docampo
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:mBio
Subjects:
acidocalcisome
alkalinization
histidine ammonia lyase
polyphosphate
Trypanosoma cruzi
Online Access:https://journals.asm.org/doi/10.1128/mBio.01981-21

Internet

https://journals.asm.org/doi/10.1128/mBio.01981-21

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