LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain

LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain

Age-related decline in mitochondrial function and oxidative stress plays a critical role in neurodegeneration. Lactate dehydrogenase-B (LDHB) is a glycolytic enzyme that catalyzes the conversion of lactate, an important brain energy substrate, into pyruvate. It has been reported that the LDHB patter...

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Bibliographic Details
Main Authors: Jun Sung Park, Kamran Saeed, Myeung Hoon Jo, Min Woo Kim, Hyeon Jin Lee, Chan-Bae Park, Gwang Lee, Myeong Ok Kim
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antioxidants
Subjects:
Lactate dehydrogenase-B
mitochondrial dysfunction
oxidative stress
inflammation
p-AMPK/Sirt1/PGC-1alpha signaling
osmotin
Online Access:https://www.mdpi.com/2076-3921/11/2/261

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https://www.mdpi.com/2076-3921/11/2/261

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