Evaluating the Genotoxic and Cytotoxic Effects of Thymidine Analogs, 5-Ethynyl-2′-Deoxyuridine and 5-Bromo-2′-Deoxyurdine to Mammalian Cells

Evaluating the Genotoxic and Cytotoxic Effects of Thymidine Analogs, 5-Ethynyl-2′-Deoxyuridine and 5-Bromo-2′-Deoxyurdine to Mammalian Cells

BrdU (bromodeoxyuridine) and EdU (ethynyldeoxyuridine) have been largely utilized as the means of monitoring DNA replication and cellular division. Although BrdU induces gene and chromosomal mutations and induces sensitization to photons, EdU‘s effects have not been extensively studied yet. Therefor...

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Bibliographic Details
Main Authors: Jeremy S. Haskins, Cathy Su, Junko Maeda, Kade D. Walsh, Alexis H. Haskins, Allison J. Allum, Coral E. Froning, Takamitsu A. Kato
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
EdU
BrdU
radiosensitizer
DNA repair
Online Access:https://www.mdpi.com/1422-0067/21/18/6631

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https://www.mdpi.com/1422-0067/21/18/6631

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