Calcitonin Related Polypeptide Alpha Mediates Oral Cancer Pain

Calcitonin Related Polypeptide Alpha Mediates Oral Cancer Pain

Oral cancer patients suffer pain at the site of the cancer. Calcitonin gene related polypeptide (CGRP), a neuropeptide expressed by a subset of primary afferent neurons, promotes oral cancer growth. CGRP also mediates trigeminal pain (migraine) and neurogenic inflammation. The contribution of CGRP t...

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Bibliographic Details
Main Authors: Nguyen Huu Tu, Kenji Inoue, Parker K. Lewis, Ammar Khan, Jun Hyeong Hwang, Varun Chokshi, Branka Brukner Dabovic, Shanmugapriya Selvaraj, Aditi Bhattacharya, Zinaida Dubeykovskaya, Nathalie M. Pinkerton, Nigel W. Bunnett, Cynthia A. Loomis, Donna G. Albertson, Brian L. Schmidt
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
oral cancer
pain
CGRP
peptidergic neurons
CALCRL/RAMP1
cancer innervation
Online Access:https://www.mdpi.com/2073-4409/12/13/1675

Internet

https://www.mdpi.com/2073-4409/12/13/1675

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