The plasma kynurenine-to-tryptophan ratio as a biomarker of tuberculosis disease in people living with HIV on antiretroviral therapy: an exploratory nested case–control study

The plasma kynurenine-to-tryptophan ratio as a biomarker of tuberculosis disease in people living with HIV on antiretroviral therapy: an exploratory nested case–control study

Abstract Background Non-sputum-based tests are needed to predict or diagnose tuberculosis (TB) disease in people living with HIV (PWH). The enzyme indoleamine 2, 3-dioxygenase-1 (IDO1) is expressed in tuberculoid granuloma and catabolizes tryptophan (Trp) to kynurenine (Kyn). IDO1 activity compromis...

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Bibliographic Details
Main Authors: Sivaporn Gatechompol, René Lutter, Frédéric M. Vaz, Sasiwimol Ubolyam, Anchalee Avihingsanon, Stephen J. Kerr, Frank van Leth, Frank Cobelens
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Infectious Diseases
Subjects:
IDO
Tuberculosis
HIV
Diagnostic
Monitoring
Online Access:https://doi.org/10.1186/s12879-024-09258-4

Internet

https://doi.org/10.1186/s12879-024-09258-4

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