Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR)

Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR)

ABSTRACT Protein kinase R (PKR) plays a major role in activating host immunity during infection by sensing double-stranded RNA (dsRNA) produced by viruses. Once activated by dsRNA, PKR phosphorylates the translation factor eukaryotic initiation factor 2α (eIF2α), halting cellular translation. Many v...

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Bibliographic Details
Main Authors: Danielle E. Goodman, Carla D. Pretto, Tomas A. Krepostman, Kelly E. Carnahan, Katherine R. Spindler
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mBio
Subjects:
PKR
adenoviruses
eIF2alpha kinase
proteasome
protein degradation
protein stability
Online Access:https://journals.asm.org/doi/10.1128/mBio.00668-19

Internet

https://journals.asm.org/doi/10.1128/mBio.00668-19

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