TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation

Abstract Obesity and high-fat diet (HFD) consumption result in hypothalamic inflammation and metabolic dysfunction. While the TLR4 activation by dietary fats is a well-characterized pathway involved in the neuronal and glial inflammation, the role of its accessory proteins in diet-induced hypothalam...

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Bibliographic Details
Main Authors: Alexandre Moura-Assis, Pedro A. S. Nogueira, Jose C. de-Lima-Junior, Fernando M. Simabuco, Joana M. Gaspar, Jose Donato Jr, Licio A. Velloso
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97291-7