Development and characterization of PLGA-Bupivacaine and PLGA-S75:R25 Bupivacaine (Novabupi®) biodegradable implants for postoperative pain

Abstract In the hospital environment, postoperative pain is a common occurrence that impairs patient recovery and rehabilitation and lengthens hospitalization time. Racemic bupivacaine hydrochloride (CBV) and Novabupi® (NBV) (S (-) 75% R (+) 25% bupivacaine hydrochloride) are two examples of local a...

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Bibliographic Details
Main Authors: Matheus Augusto de Castro, Gabriella Maria Fernandes Cunha, Gracielle Ferreira Andrade, Maria Irene Yoshida, Ana Luiza de Faria, Armando Silva-Cunha
Format: Article
Language:English
Published: Universidade de São Paulo 2023-01-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100306&tlng=en