Structural insights into the binding mechanism of Clr4 methyltransferase to H3K9 methylated nucleosome

Abstract The establishment and maintenance of heterochromatin, a specific chromatin structure essential for genomic stability and regulation, rely on intricate interactions between chromatin-modifying enzymes and nucleosomal histone proteins. However, the precise trigger for these modifications rema...

Full description

Bibliographic Details
Main Authors: Christopher Saab, Joseph Stephan, Elias Akoury
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-56248-2