Binding Modes of Xanthine‐Derived Selective Allosteric Site Inhibitors of MTHFD2

Binding Modes of Xanthine‐Derived Selective Allosteric Site Inhibitors of MTHFD2

Abstract Methylenetetrahydrofolate dehydrogenase (MTHFD2) is a mitochondrial enzyme involved in 1 C metabolism that is upregulated in various cancer cells, but absent in normal proliferating cells. Xanthine derivatives are the first selective inhibitors of MTHFD2 which bind to its allosteric site. X...

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Bibliographic Details
Main Authors: Dr. Vibhu Jha, Prof. Dr. Leif A. Eriksson
Format: Article
Language:English
Published: Wiley-VCH 2023-05-01
Series:ChemistryOpen
Subjects:
allosteric site
conformational changes
molecular dynamics simulations
molecular modeling
xanthine-derived MTHFD2 inhibitors
Online Access:https://doi.org/10.1002/open.202300052

Internet

https://doi.org/10.1002/open.202300052

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