Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

The Xist lncRNA mediates X chromosome inactivation (XCI). Here we show that Spen, an Xist-binding repressor protein essential for XCI , binds to ancient retroviral RNA, performing a surveillance role to recruit chromatin silencing machinery to these parasitic loci. Spen loss activates a subset of en...

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Bibliographic Details
Main Authors: Ava C Carter, Jin Xu, Meagan Y Nakamoto, Yuning Wei, Brian J Zarnegar, Quanming Shi, James P Broughton, Ryan C Ransom, Ankit Salhotra, Surya D Nagaraja, Rui Li, Diana R Dou, Kathryn E Yost, Seung-Woo Cho, Anil Mistry, Michael T Longaker, Paul A Khavari, Robert T Batey, Deborah S Wuttke, Howard Y Chang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
Xist
long noncoding RNA
transposon
chromatin
epigenetic
gene silencing
Online Access:https://elifesciences.org/articles/54508

Internet

https://elifesciences.org/articles/54508

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