The β2-adrenergic receptor in the apical membrane of intestinal enterocytes senses sugars to stimulate glucose uptake from the gut

The β2-adrenergic receptor in the apical membrane of intestinal enterocytes senses sugars to stimulate glucose uptake from the gut

The presence of sugar in the gut causes induction of SGLT1, the sodium/glucose cotransporter in intestinal epithelial cells (enterocytes), and this is accompanied by stimulation of sugar absorption. Sugar sensing was suggested to involve a G-protein coupled receptor and cAMP - protein kinase A signa...

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Bibliographic Details
Main Authors: Frederik Paulussen, Chetan P. Kulkarni, Frank Stolz, Eveline Lescrinier, Stijn De Graeve, Suzan Lambin, Arnaud Marchand, Patrick Chaltin, Peter In't Veld, Joseph Mebis, Jan Tavernier, Patrick Van Dijck, Walter Luyten, Johan M. Thevelein
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
glucose sensing
gut
enterocytes
Beta2-adrenergic receptor
glucose transport
SGLT1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1041930/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.1041930/full

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