Feasibility and diagnostic utility of antigen-specific interferon-gamma responses for rapid immunodiagnosis of tuberculosis using induced sputum.

Feasibility and diagnostic utility of antigen-specific interferon-gamma responses for rapid immunodiagnosis of tuberculosis using induced sputum.

The diagnosis of smear-negative or sputum-scarce tuberculosis (TB) is problematic as culture takes several weeks and representative biological samples are difficult to obtain. RD-1 antigen-specific interferon-gamma release assays (IGRAs) are sensitive and specific blood-based tests for the diagnosis...

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Bibliographic Details
Main Authors: Tamaryn J Cashmore, Jonathan G Peter, Richard N van Zyl-Smit, Patricia L Semple, Alice Maredza, Richard Meldau, Alimuddin Zumla, Barbara Nurse, Keertan Dheda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2861000?pdf=render

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http://europepmc.org/articles/PMC2861000?pdf=render

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