Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems

Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems

In vitro two-dimensional (2D) and three-dimensional (3D) cultivation of mammalian cells requires supplementation with serum. Mesenchymal stem cells (MSCs) are widely used in clinical trials for bioregenerative medicine and in most cases, in vitro expansion and differentiation of these cells are requ...

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Bibliographic Details
Main Authors: Marline Kirsch, Jessica Rach, Wiebke Handke, Axel Seltsam, Iliyana Pepelanova, Sarah Strauß, Peter Vogt, Thomas Scheper, Antonina Lavrentieva
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
platelet lysate
mesenchymal stem cells
differentiation
medium supplements
fetal calf serum
human serum
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.598389/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2020.598389/full

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