Toll-Like Receptor-2 Ligand Peptidoglycan Upregulates Expression and Ubiquitin Ligase Activity of CHIP through JNK Pathway

Toll-Like Receptor-2 Ligand Peptidoglycan Upregulates Expression and Ubiquitin Ligase Activity of CHIP through JNK Pathway

Background: Peptidoglycan (PGN) is a component of cell wall in Gram-positive bacteria that stimulates inflammatory responses through Toll-like receptor 2 (TLR2). The carboxyl terminus of constitutive heat shock cognate 70 (HSC70)-interacting protein (CHIP, also known as Stub1) is a U-box-type E3 ubi...

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Bibliographic Details
Main Authors: Yan Meng, Chen Chen, Lei Wang, Xia Wang, Cui Tian, Jie Du, Hui-Hua Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
CHIP
Peptidoglycan
Inflammation
Ubquitination
JNK
Online Access:http://www.karger.com/Article/FullText/354509

Internet

http://www.karger.com/Article/FullText/354509

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