Combined TP53 status in tumor-free resection margins and circulating microRNA profiling predicts the risk of locoregional recurrence in head and neck cancer

Combined TP53 status in tumor-free resection margins and circulating microRNA profiling predicts the risk of locoregional recurrence in head and neck cancer

Abstract Locoregional recurrences represent a frequently unexpected problem in head and neck squamous cell carcinoma (HNSCC). Relapse often (10–30%) occurs in patients with histologically negative resection margins (RMs), probably due to residual tumor cells or hidden pre-cancerous lesions in normal...

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Bibliographic Details
Main Authors: Federica Ganci, Matteo Allegretti, Carlotta Frascolla, Francesca Spinella, Francesca Rollo, Andrea Sacconi, Pascale De Valentina, Alina Catalina Palcau, Valentina Manciocco, Mariavittoria Vescovo, Ettore Cotroneo, Francesca Blandino, Maria Benevolo, Renato Covello, Paola Muti, Sabrina Strano, Antonello Vidiri, Giulia Fontemaggi, Raul Pellini, Giovanni Blandino
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Biomarker Research
Subjects:
HNSCC
Resection margins
Local recurrence
TP53
microRNA profiling
Liquid biopsy
Online Access:https://doi.org/10.1186/s40364-024-00576-y

Internet

https://doi.org/10.1186/s40364-024-00576-y

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