Sortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells

Sortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells

Abstract The selective transport to lysosomes can be mediated by either mannose-6-phosphate receptors (CD-MPR and CI-MPR) or sortilin. In mammalian epididymis, some lysosomal proteins are secreted into the lumen through unknown mechanisms. To investigate the underlying mechanisms of lysosomal protei...

Full description

Bibliographic Details
Main Authors: Andrea Carolina Aguilera, Natalia Leiva, Pablo Ariel Alvarez, Georgina Pulcini, Laura Lucía Pereyra, Carlos Ramón Morales, Miguel Ángel Sosa, Lorena Carvelli
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-29157-z

Internet

https://doi.org/10.1038/s41598-023-29157-z

Similar Items