PPARγ-activation increases intestinal M1 macrophages and mitigates formation of serrated adenomas in mutant KRAS mice

PPARγ-activation increases intestinal M1 macrophages and mitigates formation of serrated adenomas in mutant KRAS mice

To identify novel hubs for cancer immunotherapy, we generated C57BL/6J mice with concomitant deletion of the drugable transcription factor PPARγ and transgenic overexpression of the mutant KRASG12V oncogene in enterocytes. Animals developed epithelial hyperplasia, transmural inflammation and serrate...

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Bibliographic Details
Main Authors: Tobias Gutting, Christian A. Weber, Philip Weidner, Frank Herweck, Sarah Henn, Teresa Friedrich, Shuiping Yin, Julia Kzhyshkowska, Timo Gaiser, Klaus-Peter Janssen, Wolfgang Reindl, Matthias P. A. Ebert, Elke Burgermeister
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:OncoImmunology
Subjects:
colorectal cancer
macrophages
ppar
ras
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1423168

Internet

http://dx.doi.org/10.1080/2162402X.2017.1423168

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