Biomimetic “Gemini nanoimmunoregulators” orchestrated for boosted photoimmunotherapy by spatiotemporally modulating PD-L1 and tumor-associated macrophages

Biomimetic “Gemini nanoimmunoregulators” orchestrated for boosted photoimmunotherapy by spatiotemporally modulating PD-L1 and tumor-associated macrophages

A novel strategy of not only stimulating the immune cycle but also modulating the immunosuppressive tumor microenvironment is of vital importance to efficient cancer immunotherapy. Here, a new type of spatiotemporal biomimetic “Gemini nanoimmunoregulators” was engineered to activate robust systemic...

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Bibliographic Details
Main Authors: Honglin Huang, Ningxi Li, Xiaodan Wei, Qingzhi Li, Junhan Guo, Geng Yang, Hong Yang, Lulu Cai, Yiyao Liu, Chunhui Wu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Biomimetic immunoregulator
Spatiotemporal delivery
Targeted photothermal therapy
Amplified immunogenic cell death
Immunosuppressive tumor microenvironment
PD-L1 degradation
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352300429X

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http://www.sciencedirect.com/science/article/pii/S221138352300429X

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