Highly Effective Non-Viral Antitumor Gene Therapy System Comprised of Biocompatible Small Plasmid Complex Particles Consisting of pDNA, Anionic Polysaccharide, and Fully Deprotected Linear Polyethylenimine

Highly Effective Non-Viral Antitumor Gene Therapy System Comprised of Biocompatible Small Plasmid Complex Particles Consisting of pDNA, Anionic Polysaccharide, and Fully Deprotected Linear Polyethylenimine

We have reported that ternary complexes of plasmid DNA with conventional linear polyethylenimine (l-PEI) and certain polyanions were very stably dispersed, and, with no cryoprotectant, they could be freeze-dried and re-hydrated without the loss of transfection ability. These properties enabled the p...

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Bibliographic Details
Main Authors: Yoshiyuki Koyama, Kikuya Sugiura, Chieko Yoshihara, Toshio Inaba, Tomoko Ito
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Pharmaceutics
Subjects:
non-viral
transfection
plasmid
Polyethylenimine “Max”
freeze-drying
hyaluronic acid
chondroitin sulfate
antitumor
cytokine
nanoparticle
Online Access:http://www.mdpi.com/1999-4923/7/3/152

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http://www.mdpi.com/1999-4923/7/3/152

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