A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs

A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs

Abstract Background We previously reported a familial thyroid follicular cell carcinoma (FCC) in a large number of Dutch German longhaired pointers and identified two deleterious germline mutations in the TPO gene associated with disease predisposition. However, the somatic mutation profile of the F...

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Bibliographic Details
Main Authors: Yun Yu, Freek Manders, Guy C. M. Grinwis, Martien A. M. Groenen, Richard P. M. A. Crooijmans
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Genomics
Subjects:
Familial cancer
Thyroid carcinoma
Driver mutation
Dog
GNAS
Mutational signature
Online Access:https://doi.org/10.1186/s12864-022-08885-y

Internet

https://doi.org/10.1186/s12864-022-08885-y

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