An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer

An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer

Abstract Background Pancreatic cancer is a deadly disease with a very low 5-year patient survival rate of 6–8%. The major challenges of eliminating pancreatic cancer are treatment resistance and stromal barriers to optimal drug access within the tumor. Therefore, effective molecular targeting drugs...

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Bibliographic Details
Main Authors: Xiang Ling, Wenjie Wu, Chuandong Fan, Chao Xu, Jianqun Liao, Laurie J. Rich, Ruea-Yea Huang, Elizabeth A. Repasky, Xinjiang Wang, Fengzhi Li
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
FL118
Stem-like cancer cells
Survivin
Orthotopic pancreatic cancer model
Human pancreatic cancer patient-derived xenograft (PDX) animal models
Online Access:http://link.springer.com/article/10.1186/s13046-018-0899-8

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http://link.springer.com/article/10.1186/s13046-018-0899-8

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