3, 3′- (3, 5-DCPBC) Down-Regulates Multiple Phosphokinase Dependent Signal Transduction Pathways in Malignant Melanoma Cells through Specific Diminution of EGFR<sup>Y1086</sup> Phosphorylation

3, 3′- (3, 5-DCPBC) Down-Regulates Multiple Phosphokinase Dependent Signal Transduction Pathways in Malignant Melanoma Cells through Specific Diminution of EGFR<sup>Y1086</sup> Phosphorylation

Melanoma is the most dangerous skin malignancy due to its strong metastatic potential with high mortality. Activation of crucial signaling pathways enforcing melanoma progression depends on phosphorylation of distinct tyrosine kinases and oxidative stress. We here investigated the effect of a <i&...

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Bibliographic Details
Main Authors: Qurat-ul-Ain, Abhijit Basu, M. Iqbal Choudhary, Karin Scharffetter-Kochanek
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
melanoma
<i>bis</i>-coumarin
tyrosine kinases
phosphorylation
phosphokinases
migration
Online Access:https://www.mdpi.com/1420-3049/27/4/1172

Internet

https://www.mdpi.com/1420-3049/27/4/1172

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