Discrepant Activation Pattern of Inflammation and Pyroptosis Induced in Dermal Fibroblasts in Response to Dengue Virus Serotypes 1 and 2 and Nonstructural Protein 1

Discrepant Activation Pattern of Inflammation and Pyroptosis Induced in Dermal Fibroblasts in Response to Dengue Virus Serotypes 1 and 2 and Nonstructural Protein 1

ABSTRACT Four serotypes of dengue virus (DENV-1 to DENV-4) cause mild to severe disease in humans through infected mosquito bites. Dermal fibroblasts were found to be susceptible to DENV, and this may play a critical role in establishing the initial infection stage. However, the cellular response in...

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Bibliographic Details
Main Authors: Kai-Che Wei, Wan-Ju Wei, Ching-Len Liao, Tsung-Hsien Chang
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
dengue virus
NS1
pyroptosis
caspase-1
IL-1β
dermal fibroblasts
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03586-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03586-22

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