O-Acetyl-GD2 as a Therapeutic Target for Breast Cancer Stem Cells

O-Acetyl-GD2 as a Therapeutic Target for Breast Cancer Stem Cells

SynopsisA sugar-lipid molecule called OAcGD2 is a novel marker for breast cancer stem cells. Treatment with anti-OAcGD2 mAb8B6 may have superior anticancer efficacy by targeting cancer stem cells, thereby reducing metastasis and recurrence of cancer.BackgroundCancer stem cells (CSCs) that drive tumo...

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Bibliographic Details
Main Authors: Jing-Yan Cheng, Jung-Tung Hung, Juway Lin, Fei-Yun Lo, Jing-Rong Huang, Shih-Pin Chiou, Ya-Hui Wang, Ruey-Jen Lin, Jen-Chine Wu, John Yu, Alice L. Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
glycosphingolipid (GSL) glycans
breast cancer stem cells markers
immunotherapy
antibody
PDX (patient-derived xenografts)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.791551/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.791551/full

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