Identification of Lenalidomide Sensitivity and Resistance Mechanisms in Non-Del(5q) Myelodysplastic Syndromes

Identification of Lenalidomide Sensitivity and Resistance Mechanisms in Non-Del(5q) Myelodysplastic Syndromes

Whereas lenalidomide is an effective therapy for del(5q) MDS patients, a minority of non-del(5q) MDS patients achieve hematologic improvement with lenalidomide. We used computational biology modeling and digital drug simulation to examine genomic data from 56 non-del(5q) MDS patients treated with le...

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Bibliographic Details
Main Authors: Leylah M. Drusbosky, Christopher R. Cogle
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
myelodysplastic syndromes
refractory disease
resistance
computational modeling
Online Access:https://www.mdpi.com/1422-0067/21/9/3323

Internet

https://www.mdpi.com/1422-0067/21/9/3323

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