IL-6 and IL-8 Are Linked With Myeloid-Derived Suppressor Cell Accumulation and Correlate With Poor Clinical Outcomes in Melanoma Patients

IL-6 and IL-8 Are Linked With Myeloid-Derived Suppressor Cell Accumulation and Correlate With Poor Clinical Outcomes in Melanoma Patients

We sought to identify tumor-secreted factors that altered the frequency of MDSCs and correlated with clinical outcomes in advanced melanoma patients. We focused our study on several of the many factors involved in the expansion and mobilization of MDSCs. These were identified by measuring circulatin...

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Bibliographic Details
Main Authors: Richard P. Tobin, Kimberly R. Jordan, Puja Kapoor, Eric Spongberg, Dana Davis, Victoria M. Vorwald, Kasey L. Couts, Dexiang Gao, Derek E. Smith, Jessica S. W. Borgers, Steven Robinson, Carol Amato, Rene Gonzalez, Karl D. Lewis, William A. Robinson, Virginia F. Borges, Martin D. McCarter
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
cytokine
immunosuppression
melanoma
MDSC
long-term survival
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01223/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01223/full

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