Proteotoxicity caused by perturbed protein complexes underlies hybrid incompatibility in yeast

Hybrid incompatibility can be an important element of reproductive isolation and speciation. Using chromosome replacement lines of yeast, the authors show that perturbed proteostasis caused by destabilized hybrid protein complexes may represent a general mechanism of hybrid incompatibility.

Bibliographic Details
Main Authors: Krishna B. S. Swamy, Hsin-Yi Lee, Carmina Ladra, Chien-Fu Jeff Liu, Jung-Chi Chao, Yi-Yun Chen, Jun-Yi Leu
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32107-4