Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion.

Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion.

BACKGROUND:Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in DNA and 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the major lesions formed. It is amongst the most mutagenic lesions in cells because of its dual coding potential, wherein 8-oxoG(syn) can pair with an...

Full description

Bibliographic Details
Main Authors: Rodrigo Vasquez-Del Carpio, Timothy D Silverstein, Samer Lone, Michael K Swan, Jayati R Choudhury, Robert E Johnson, Satya Prakash, Louise Prakash, Aneel K Aggarwal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2686167?pdf=render

Internet

http://europepmc.org/articles/PMC2686167?pdf=render

Similar Items