Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Abstract Background Vitamin E δ-tocotrienol (VEDT), a vitamin E compound isolated from sources such as palm fruit and annatto beans, has been reported to have cancer chemopreventive and therapeutic effects. Methods We report a novel function of VEDT in augmenting tumor necrosis factor-related apopto...

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Bibliographic Details
Main Authors: Rony A. Francois, Anying Zhang, Kazim Husain, Chen Wang, Sean Hutchinson, Michael Kongnyuy, Surinder K. Batra, Domenico Coppola, Said M. Sebti, Mokenge P. Malafa
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cancer Cell International
Subjects:
δ-Tocotrienol
Pancreatic cancer
Apoptosis
TRAIL
c-FLIP
Online Access:http://link.springer.com/article/10.1186/s12935-019-0876-0

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http://link.springer.com/article/10.1186/s12935-019-0876-0

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