Nucleation of cadherin clusters on cell-cell interfaces
Abstract Cadherins mediate cell-cell adhesion and help the cell determine its shape and function. Here we study collective cadherin organization and interactions within cell-cell contact areas, and find the cadherin density at which a ‘gas-liquid’ phase transition occurs, when cadherin monomers begi...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23220-x |
| _version_ | 1797984760117592064 |
|---|---|
| author | Neil Ibata Eugene M. Terentjev |
| author_facet | Neil Ibata Eugene M. Terentjev |
| author_sort | Neil Ibata |
| collection | DOAJ |
| description | Abstract Cadherins mediate cell-cell adhesion and help the cell determine its shape and function. Here we study collective cadherin organization and interactions within cell-cell contact areas, and find the cadherin density at which a ‘gas-liquid’ phase transition occurs, when cadherin monomers begin to aggregate into dense clusters. We use a 2D lattice model of a cell-cell contact area, and coarse-grain to the continuous number density of cadherin to map the model onto the Cahn-Hilliard coarsening theory. This predicts the density required for nucleation, the characteristic length scale of the process, and the number density of clusters. The analytical predictions of the model are in good agreement with experimental observations of cadherin clustering in epithelial tissues. |
| first_indexed | 2024-04-11T07:06:47Z |
| format | Article |
| id | doaj.art-4b20697a289e47b4890e548e359431d5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T07:06:47Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4b20697a289e47b4890e548e359431d52022-12-22T04:38:22ZengNature PortfolioScientific Reports2045-23222022-11-0112111210.1038/s41598-022-23220-xNucleation of cadherin clusters on cell-cell interfacesNeil Ibata0Eugene M. Terentjev1Cavendish Laboratory, University of CambridgeCavendish Laboratory, University of CambridgeAbstract Cadherins mediate cell-cell adhesion and help the cell determine its shape and function. Here we study collective cadherin organization and interactions within cell-cell contact areas, and find the cadherin density at which a ‘gas-liquid’ phase transition occurs, when cadherin monomers begin to aggregate into dense clusters. We use a 2D lattice model of a cell-cell contact area, and coarse-grain to the continuous number density of cadherin to map the model onto the Cahn-Hilliard coarsening theory. This predicts the density required for nucleation, the characteristic length scale of the process, and the number density of clusters. The analytical predictions of the model are in good agreement with experimental observations of cadherin clustering in epithelial tissues.https://doi.org/10.1038/s41598-022-23220-x |
| spellingShingle | Neil Ibata Eugene M. Terentjev Nucleation of cadherin clusters on cell-cell interfaces Scientific Reports |
| title | Nucleation of cadherin clusters on cell-cell interfaces |
| title_full | Nucleation of cadherin clusters on cell-cell interfaces |
| title_fullStr | Nucleation of cadherin clusters on cell-cell interfaces |
| title_full_unstemmed | Nucleation of cadherin clusters on cell-cell interfaces |
| title_short | Nucleation of cadherin clusters on cell-cell interfaces |
| title_sort | nucleation of cadherin clusters on cell cell interfaces |
| url | https://doi.org/10.1038/s41598-022-23220-x |
| work_keys_str_mv | AT neilibata nucleationofcadherinclustersoncellcellinterfaces AT eugenemterentjev nucleationofcadherinclustersoncellcellinterfaces |