Molecular Evaluation of the Impact of Polymorphic Variants in Apoptotic (<i>Bcl-2/Bax</i>) and Proinflammatory Cytokine (<i>TNF-α/IL-8</i>) Genes on the Susceptibility and Progression of Myeloproliferative Neoplasms: A Case-Control Biomarker Study

Molecular Evaluation of the Impact of Polymorphic Variants in Apoptotic (<i>Bcl-2/Bax</i>) and Proinflammatory Cytokine (<i>TNF-α/IL-8</i>) Genes on the Susceptibility and Progression of Myeloproliferative Neoplasms: A Case-Control Biomarker Study

The regulation of apoptosis (the programmed cell death) is dependent on the crucial involvement of BCL2 and BAX. The <i>Bax-248G>A</i> and <i>Bcl-2-938 C>A</i> polymorphic variations in the promoter sequences of the <i>Bax</i> and <i>Bcl-2</i> ge...

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Bibliographic Details
Main Authors: Mamdoh S. Moawadh, Rashid Mir, Faris J. Tayeb, Orooba Asim, Mohammad Fahad Ullah
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Current Issues in Molecular Biology
Subjects:
single nucleotide polymorphisms
apoptosis
gene promoter
proinflammatory cytokines
MPDs
CML—chronic myeloid leukaemia
Online Access:https://www.mdpi.com/1467-3045/45/5/251

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https://www.mdpi.com/1467-3045/45/5/251

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