Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology

Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology

Abstract Objectives Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a significant medical challenge, with no indisputable pathophysiological mechanism identified to date. Methods Based on clinical clues, we hypothesized that 5-hydroxytryptamine (5-HT) hyperactivation is implicated in...

Full description

Bibliographic Details
Main Authors: Jin-Seok Lee, Ji-Yun Kang, Samuel-Young Park, Seung-Ju Hwang, Sung-Jin Bae, Chang-Gue Son
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Translational Medicine
Subjects:
Myalgic encephalomyelitis/chronic fatigue syndrome
Fatigue, serotonin
5-HT1A receptor
Desensitization
Hypocortisolism
Online Access:https://doi.org/10.1186/s12967-023-04808-x

Internet

https://doi.org/10.1186/s12967-023-04808-x

Similar Items