Novel IMB16-4 Compound Loaded into Silica Nanoparticles Exhibits Enhanced Oral Bioavailability and Increased Anti-Liver Fibrosis In Vitro

Novel IMB16-4 Compound Loaded into Silica Nanoparticles Exhibits Enhanced Oral Bioavailability and Increased Anti-Liver Fibrosis In Vitro

Background: Liver fibrosis, as a common and refractory disease, is challenging to treat due to the lack of effective agents worldwide. Recently, we have developed a novel compound, N-(3,4,5-trichlorophenyl)-2(3-nitrobenzenesulfonamide) benzamide (IMB16-4), which is expected to have good potential ef...

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Bibliographic Details
Main Authors: Xia Niu, Xiaomei Wang, Bingyu Niu, Guoqing Li, Xinyi Yang, Yucheng Wang, Guiling Li
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
mesoporous silica nanoparticle
liver fibrosis
oral bioavailability
TGF-β1
dissolution rate
Online Access:https://www.mdpi.com/1420-3049/26/6/1545

Internet

https://www.mdpi.com/1420-3049/26/6/1545

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