Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

Abstract Background Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer associated genes using the prostate cancer cell line PC3 as a mode...

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Bibliographic Details
Main Authors: Elizabeth Bowler, Sean Porazinski, Simon Uzor, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Kasper M. A. Rouschop, John Hancock, Ian Wilson, Michael Ladomery
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
Hypoxia
Alternative splicing
Prostate cancer
Apoptosis
Splice factors
Splice factor kinases
Online Access:http://link.springer.com/article/10.1186/s12885-018-4227-7

Internet

http://link.springer.com/article/10.1186/s12885-018-4227-7

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