Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity.

Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity.

Thyroid peroxidase (TPO) catalyses the biosynthesis of thyroid hormones and is a major autoantigen in Hashimoto's disease--the most common organ-specific autoimmune disease. Epitope mapping studies have shown that the autoimmune response to TPO is directed mainly at two surface regions on the m...

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Bibliographic Details
Main Authors: Sarah N Le, Benjamin T Porebski, Julia McCoey, James Fodor, Blake Riley, Marlena Godlewska, Monika Góra, Barbara Czarnocka, J Paul Banga, David E Hoke, Itamar Kass, Ashley M Buckle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4666655?pdf=render

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http://europepmc.org/articles/PMC4666655?pdf=render

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