Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity.

Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity.

Thyroid peroxidase (TPO) catalyses the biosynthesis of thyroid hormones and is a major autoantigen in Hashimoto's disease--the most common organ-specific autoimmune disease. Epitope mapping studies have shown that the autoimmune response to TPO is directed mainly at two surface regions on the m...

Full description

Bibliographic Details
Main Authors:	Sarah N Le, Benjamin T Porebski, Julia McCoey, James Fodor, Blake Riley, Marlena Godlewska, Monika Góra, Barbara Czarnocka, J Paul Banga, David E Hoke, Itamar Kass, Ashley M Buckle
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4666655?pdf=render

Similar Items

Biochemical properties of thyroid peroxidase (TPO) expressed in human breast and mammary-derived cell lines.
by: Marlena Godlewska, et al.
Published: (2018-01-01)

The Role of Conformational Dynamics in Abacavir-Induced Hypersensitivity Syndrome
by: James Fodor, et al.
Published: (2019-07-01)

Autoantigen recognition by thyroid-infiltrating T cells in Graves disease.
by: Dayan, C, et al.
Published: (1991)

The nature of autoantigens
by: Ivan M. Roitt, et al.
Published: (1987-01-01)

Immunogenicity of autoantigens
by: Keller Andreas, et al.
Published: (2011-07-01)

Transfection of thyroid autoantigens into EBV-transformed B cell lines. Recognition by Graves' disease thyroid T cells.
by: Mullins, R, et al.
Published: (1994)

Vitiligo – Anti-thyroid peroxidase antibody
by: Anca Chiriac, et al.
Published: (2012-07-01)

Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease.
by: Dale, R, et al.
Published: (2006)

Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1
by: Casey J. A. Smith-Anttila, et al.
Published: (2017-05-01)

Novel Inhibitor-Based Therapies for Thyroid Cancer—An Update
by: Maciej Ratajczak, et al.
Published: (2021-10-01)

Interferon and autoantigens: intersection in autoimmunity
by: Brendan Antiochos, et al.
Published: (2023-05-01)

Autoantigen Treatment in Type 1 Diabetes: Unsolved Questions on How to Select Autoantigen and Administration Route
by: Johnny Ludvigsson
Published: (2020-02-01)

Simultaneous Determination of Manganese Peroxidase and Lignin Peroxidase by Capillary Electrophoresis Enzyme Assays
by: Sumire Kudo, et al.
Published: (2017-10-01)

The Effect of Anti-Thyroid Peroxidase Antibodies on Pregnancy Outcomes in Euthyroid Women
by: Monika Meena, et al.
Published: (2016-09-01)

Characterization of peroxidase enzyme and detoxification of phenols using peroxidase enzyme obtained from Zea mays L waste
by: S. Lakshmi, et al.
Published: (2018-10-01)

Thyroid peroxidase activity is inhibited by amino acids
by: D.P. Carvalho, et al.
Published: (2000-03-01)

Reactivity to Novel Autoantigens in Patients with Coexisting Central Nervous System Demyelinating Disease and Autoimmune Thyroid Disease
by: Judith M. Greer, et al.
Published: (2017-05-01)

Relationship of thyroid peroxidase antibody test with abnormal thyroid function tests
by: Srijana Khadka Shrestha, et al.
Published: (2017-09-01)

Evaluation of epitopes specificity of antibodies to thyroid peroxidase in autoimmune thyroid disorders
Published: (2011-06-01)

Cellular and molecular basis of thyroid autoimmunity
by: Joanna Bogusławska, et al.
Published: (2023-01-01)

Biochemistry of drug-dependent platelet autoantigens
by: Preeyanat Pvongchan
Published: (2011-05-01)

NETosis as source of autoantigens in rheumatoid arthritis
by: Elisa Corsiero, et al.
Published: (2016-11-01)

Novel autoantigens immunogenic in COPD patients
by: Stephan Bernhard, et al.
Published: (2009-03-01)

Novel Autoantigens Associated with Lupus Nephritis.
by: Sachiko Onishi, et al.
Published: (2015-01-01)

Amino acid sequence homology between thyroid autoantigens and central nervous system proteins: Implications for the steroid-responsive encephalopathy associated with autoimmune thyroiditis
by: Salvatore Benvenga, et al.
Published: (2021-12-01)

PREVALENCE OF AUTOANTIBODIES TO THYROID PEROXIDASE AND AUTOIMMUNE THYROID DISEASE IN GIRLS WITH TURNER’S SYNDROME
by: H. Moayeri Z. Oloomi
Published: (2006-07-01)

Prevalence of thyroid dysfunction and anti–thyroid peroxidase antibody in gestational diabetes mellitus
by: Arun Karat, et al.
Published: (2021-01-01)

PREVALENCE OF AUTOANTIBODIES TO THYROID PEROXIDASE AND AUTOIMMUNE THYROID DISEASE IN GIRLS WITH TURNER’S SYNDROME
by: H. Moayeri Z. Oloomi
Published: (2006-06-01)

Anti-thyroid peroxidase antibody and subclinical hypothyroidism in relation to hypertension and thyroid cysts
by: Yuji Shimizu, et al.
Published: (2020-01-01)

Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception
by: Dhillon‑Smith, R, et al.
Published: (2019)

Investigation of the impact of nonsynonymous mutations on thyroid peroxidase dimer.
by: Mst Noorjahan Begum, et al.
Published: (2023-01-01)

Anti-Thyroid Peroxidase and Risk of Recurrent Spontaneous Abortion
by: Mahnaz Ashrafi, et al.
Published: (2007-09-01)

Association of thyroid peroxidase antibody and dyslipidemia in subclinical hypothyroidism
by: Vikas Kumar Srivastava, et al.
Published: (2017-01-01)

Levels of Thyroid Peroxidase Antibodies is Higher in Threatened Abortion
by: I Nyoman A. Sanjaya, et al.
Published: (2013-07-01)

Expression of pendrin and NIS iodide transporters in human breast tumor and peri-tumoral tissue
by: Katarzyna D. Arczewska, et al.
Published: (2019-11-01)

Identification of multiple, distinct cicatritial pemphigoid autoantigens.
by: Rao, S, et al.
Published: (1996)

Reversal of immunodominance among autoantigenic T-cell epitopes.
by: Fairchild, P
Published: (1999)

Identification of Novel Native Autoantigens in Rheumatoid Arthritis
by: Thomas B. G. Poulsen, et al.
Published: (2020-05-01)

Native Autoantigen Complex Detects Pemphigoid Autoantibodies
by: Shoko Mai, et al.
Published: (2023-05-01)

Trichinella spiralis shares epitopes with human autoantigens
by: Ivana Radovic, et al.
Published: (2012-06-01)