High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature
The T cell compartment in patients with Crohn's disease is dysregulated. Here the authors use cytometric profiling to reveal an enrichment of distinct Tc17 cells during active Crohn's disease and may suggest CD6 as a potential target for therapeutic studies.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31229-z |
| _version_ | 1811328520960344064 |
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| author | A.-M. Globig A. V. Hipp P. Otto-Mora M. Heeg L. S. Mayer S. Ehl H. Schwacha M. Bewtra V. Tomov R. Thimme P. Hasselblatt B. Bengsch |
| author_facet | A.-M. Globig A. V. Hipp P. Otto-Mora M. Heeg L. S. Mayer S. Ehl H. Schwacha M. Bewtra V. Tomov R. Thimme P. Hasselblatt B. Bengsch |
| author_sort | A.-M. Globig |
| collection | DOAJ |
| description | The T cell compartment in patients with Crohn's disease is dysregulated. Here the authors use cytometric profiling to reveal an enrichment of distinct Tc17 cells during active Crohn's disease and may suggest CD6 as a potential target for therapeutic studies. |
| first_indexed | 2024-04-13T15:27:35Z |
| format | Article |
| id | doaj.art-4b2e3af4e8874ad2adc7e59066cb9554 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T15:27:35Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4b2e3af4e8874ad2adc7e59066cb95542022-12-22T02:41:28ZengNature PortfolioNature Communications2041-17232022-06-0113111510.1038/s41467-022-31229-zHigh-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signatureA.-M. Globig0A. V. Hipp1P. Otto-Mora2M. Heeg3L. S. Mayer4S. Ehl5H. Schwacha6M. Bewtra7V. Tomov8R. Thimme9P. Hasselblatt10B. Bengsch11Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center FreiburgDepartment of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center FreiburgDepartment of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center FreiburgInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center FreiburgDepartment of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center FreiburgInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center FreiburgDepartment of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center FreiburgDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of MedicineDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of MedicineDepartment of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center FreiburgDepartment of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center FreiburgDepartment of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University Medical Center FreiburgThe T cell compartment in patients with Crohn's disease is dysregulated. Here the authors use cytometric profiling to reveal an enrichment of distinct Tc17 cells during active Crohn's disease and may suggest CD6 as a potential target for therapeutic studies.https://doi.org/10.1038/s41467-022-31229-z |
| spellingShingle | A.-M. Globig A. V. Hipp P. Otto-Mora M. Heeg L. S. Mayer S. Ehl H. Schwacha M. Bewtra V. Tomov R. Thimme P. Hasselblatt B. Bengsch High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature Nature Communications |
| title | High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature |
| title_full | High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature |
| title_fullStr | High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature |
| title_full_unstemmed | High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature |
| title_short | High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature |
| title_sort | high dimensional profiling reveals tc17 cell enrichment in active crohn s disease and identifies a potentially targetable signature |
| url | https://doi.org/10.1038/s41467-022-31229-z |
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