Targeting undruggable carbohydrate recognition sites through focused fragment library design

Targeting undruggable carbohydrate recognition sites through focused fragment library design

Carbohydrate–protein interactions are key for cell–cell and host–pathogen recognition, but their hydrophilic nature makes the development of drug-like inhibitors a challenge. Here, screening of fragment libraries identifies metal-binding pharmacophores as novel scaffolds for the inhibition of Ca2+-d...

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Bibliographic Details
Main Authors: Elena Shanina, Sakonwan Kuhaudomlarp, Eike Siebs, Felix F. Fuchsberger, Maxime Denis, Priscila da Silva Figueiredo Celestino Gomes, Mads H. Clausen, Peter H. Seeberger, Didier Rognan, Alexander Titz, Anne Imberty, Christoph Rademacher
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-022-00679-3

Internet

https://doi.org/10.1038/s42004-022-00679-3

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