Modeling human early otic sensory cell development with induced pluripotent stem cells.

Modeling human early otic sensory cell development with induced pluripotent stem cells.

The inner ear represents a promising system to develop cell-based therapies from human induced pluripotent stem cells (hiPSCs). In the developing ear, Notch signaling plays multiple roles in otic region specification and for cell fate determination. Optimizing hiPSC induction for the generation of a...

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Bibliographic Details
Main Authors: Hanae Lahlou, Alejandra Lopez-Juarez, Arnaud Fontbonne, Emmanuel Nivet, Azel Zine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198954/1/pone.0198954.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T134433Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=d1b114a3da2c8e1ec217988c6a8ca0862720a79c499b8597e973d7f11322e1011af4fed4bf893b6e532bbd293e60b6efe7d0ad010b0d7f0ff367cb79922b5cfe26ecdb7707704170107ced76789fea247106f07269de1a24df525b255bf078f054d32a045fff3989f60bad15d884b632b56369c6cff7f99e917c6632401666007ae0008fa2dc0fbbe9b2bddcaa85dc122d75980c0f2a37fa40e8073b927ed661b30994df554502fbdefee7c14bfbc043ee6e5f2154d8972137a8b55dca24399860a14b346a6ab3a2e4f9b944b7aa6d092d1755f50df00431e8502272c112f8a5e5206968f3e811f2e681fd6aa65373384a7de6fd54a844d1fc7393e8d54815a2

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