α1-nAchR-Mediated Signaling Through Lipid Raft Is Required for Nicotine-Induced NLRP3 Inflammasome Activation and Nicotine-Accelerated Atherosclerosis

α1-nAchR-Mediated Signaling Through Lipid Raft Is Required for Nicotine-Induced NLRP3 Inflammasome Activation and Nicotine-Accelerated Atherosclerosis

BackgroundNicotine exerts direct effects on multiple cell types in the cardiovascular system by associating with its high-affinity nicotinic acetylcholine receptors (nAchRs). Lipid raft is a membrane microdomain that recruits various receptors and signaling molecules for coordinating cellular immune...

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Bibliographic Details
Main Authors: Fengqi Duan, Cheng Zeng, Sijun Liu, Jianfeng Gong, Jia Hu, Hongyu Li, Hongmei Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
lipid raft
nicotine
atherosclerosis
α1-nAChRs
NLRP3
inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.724699/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.724699/full

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