Platinum-based drugs induce phenotypic alterations in nucleoli and Cajal bodies in prostate cancer cells

Platinum-based drugs induce phenotypic alterations in nucleoli and Cajal bodies in prostate cancer cells

Abstract Purpose Platinum-based drugs are cytotoxic drugs commonly used in cancer treatment. They cause DNA damage, effects of which on chromatin and cellular responses are relatively well described. Yet, the nuclear stress responses related to RNA processing are incompletely known and may be releva...

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Bibliographic Details
Main Authors: Enkhzaya Batnasan, Minttu Kärkkäinen, Sonja Koivukoski, Nithin Sadeesh, Sylvain Tollis, Pekka Ruusuvuori, Mauro Scaravilli, Leena Latonen
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cancer Cell International
Subjects:
Nucleoli
Cajal bodies
Prostate cancer
Platinum drugs
Stress response
Nucleus
Online Access:https://doi.org/10.1186/s12935-023-03205-0

Internet

https://doi.org/10.1186/s12935-023-03205-0

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