Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer’s Disease-Related Pathological Progression in the Hippocampus of AppNL-G-F/NL-G-F Mice

Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer’s Disease-Related Pathological Progression in the Hippocampus of AppNL-G-F/NL-G-F Mice

Growing evidence suggests that oxidative stress due to amyloid β (Aβ) accumulation is involved in Alzheimer’s disease (AD) through the formation of amyloid plaque, which leads to hyperphosphorylation of tau, microglial activation, and cognitive deficits. The dysfunction or phenotypic loss of parvalb...

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Bibliographic Details
Main Authors: Nobuko Hongo, Yusaku Takamura, Hiroshi Nishimaru, Jumpei Matsumoto, Kazuyuki Tobe, Takashi Saito, Takaomi C. Saido, Hisao Nishijo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
astaxanthin
Alzheimer’s disease
amyloid β
parvalbumin-positive neuron
hippocampus
hyperphosphorylated tau
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00307/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00307/full

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