Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71

Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71

To date, no therapeutic agents against enterovirus 71, the causative agent of hand, foot and mouth disease, exist. Here, using Cryo-EM Huang et al. characterize two plasmablast-derived plateau-binding neutralizing antibodies conferring effective protection against lethal EV71 challenge in vivo.

Bibliographic Details
Main Authors: Kuan-Ying A. Huang, Daming Zhou, Elizabeth E. Fry, Abhay Kotecha, Peng-Nien Huang, Shu-Li Yang, Kuo-Chien Tsao, Yhu-Chering Huang, Tzou-Yien Lin, Jingshan Ren, David I. Stuart
Format: Article
Language:English
Published: Nature Portfolio 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19013-3

Internet

https://doi.org/10.1038/s41467-020-19013-3

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