Poxviruses Bearing DNA Polymerase Mutations Show Complex Patterns of Cross-Resistance

Poxviruses Bearing DNA Polymerase Mutations Show Complex Patterns of Cross-Resistance

Despite the eradication of smallpox four decades ago, poxviruses continue to be a threat to humans and animals. The arsenal of anti-poxvirus agents is very limited and understanding mechanisms of resistance to agents targeting viral DNA polymerases is fundamental for the development of antiviral the...

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Bibliographic Details
Main Authors: Graciela Andrei, Pierre Fiten, Marcela Krečmerová, Ghislain Opdenakker, Dimitrios Topalis, Robert Snoeck
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biomedicines
Subjects:
vaccinia virus
DNA polymerase
drug resistance
nucleotide analogues
cidofovir
phosphonoacetic acid
Online Access:https://www.mdpi.com/2227-9059/10/3/580

Internet

https://www.mdpi.com/2227-9059/10/3/580

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