Poxviruses Bearing DNA Polymerase Mutations Show Complex Patterns of Cross-Resistance

Poxviruses Bearing DNA Polymerase Mutations Show Complex Patterns of Cross-Resistance

Despite the eradication of smallpox four decades ago, poxviruses continue to be a threat to humans and animals. The arsenal of anti-poxvirus agents is very limited and understanding mechanisms of resistance to agents targeting viral DNA polymerases is fundamental for the development of antiviral the...

Full description

Bibliographic Details
Main Authors:	Graciela Andrei, Pierre Fiten, Marcela Krečmerová, Ghislain Opdenakker, Dimitrios Topalis, Robert Snoeck
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Series:	Biomedicines
Subjects:	vaccinia virus DNA polymerase drug resistance nucleotide analogues cidofovir phosphonoacetic acid
Online Access:	https://www.mdpi.com/2227-9059/10/3/580

Similar Items

Cidofovir Activity against Poxvirus Infections
by: Robert Snoeck, et al.
Published: (2010-12-01)

A single cidofovir treatment rescues animals at progressive stages of lethal orthopoxvirus disease
by: Israely Tomer, et al.
Published: (2012-06-01)

Poxvirus Recombination
by: David Hugh Evans
Published: (2022-08-01)

KSHV Targeted Therapy: An Update on Inhibitors of Viral Lytic Replication
by: Natacha Coen, et al.
Published: (2014-11-01)

Synthesis and Early Development of Hexadecyloxypropyl-cidofovir: An Oral Antipoxvirus Nucleoside Phosphonate
by: Karl Y. Hostetler
Published: (2010-09-01)

Development of CMX001 for the Treatment of Poxvirus Infections
by: George Painter, et al.
Published: (2010-12-01)

Assessment of Cidofovir for Treatment of Ocular Bovine Herpesvirus-1 Infection in Cattle Using an Ex-Vivo Model
by: Christopher R. Alling, et al.
Published: (2021-10-01)

Successful Outcome after Treatment with Cidofovir, Vaccinia, and Extended Course of Tecovirimat in a Newly-Diagnosed HIV Patient with Severe Mpox: A Case Report
by: Andres E. Martinez, et al.
Published: (2023-03-01)

Novel Therapeutics for Epstein–Barr Virus
by: Graciela Andrei, et al.
Published: (2019-03-01)

Neutralization Determinants on Poxviruses
by: Vernuccio Riccardo, et al.
Published: (2023-12-01)

Selection of Primer–Template Sequences That Bind with Enhanced Affinity to Vaccinia Virus E9 DNA Polymerase
by: Jeffrey J. DeStefano, et al.
Published: (2022-02-01)

Multiplex Evaluation of Biointerface-Targeting Abilities and Affinity of Synthetized Nanoparticles—A Step Towards Improved Nanoplatforms for Biomedical Applications
by: Mélanie Romain, et al.
Published: (2024-11-01)

Infecções humanas causadas por poxvirus relacionados ao vírus vaccinia no Brasil Human infections caused by vaccinia-like poxviruses in Brazil
by: Hermann G. Schatzmayr, et al.
Published: (2009-12-01)

An MHV-68 Mutator Phenotype Mutant Virus, Confirmed by CRISPR/Cas9-Mediated Gene Editing of the Viral DNA Polymerase Gene, Shows Reduced Viral Fitness
by: Erika Trompet, et al.
Published: (2021-05-01)

Suppression of Poxvirus Replication by Resveratrol
by: Shuai Cao, et al.
Published: (2017-11-01)

Ophthalmic Features and Implications of Poxviruses: Lessons from Clinical and Basic Research
by: Tolulope Fashina, et al.
Published: (2022-12-01)

Genomic identification of human vaccinia virus keratoconjunctivitis and its importance as a laboratory-acquired infection
by: Zahra Movahedi Motlagh, et al.
Published: (2016-01-01)

Why do poxviruses still matter?
by: Zhilong Yang, et al.
Published: (2021-05-01)

Challenges and Achievements in Prevention and Treatment of Smallpox
by: Sharon Melamed, et al.
Published: (2018-01-01)

Crystal structure of ethyl 2-(diethoxyphosphoryl)-2-(2,3,4-trimethoxyphenyl)acetate
by: Moritz Schubert, et al.
Published: (2014-09-01)

Poxviruses capture host genes by LINE-1 retrotransposition
by: Sarah M Fixsen, et al.
Published: (2022-09-01)

An Efficient Method for Generating Poxvirus Recombinants in the Absence of Selection
by: Stacey A. Gray, et al.
Published: (2011-03-01)

Bisbenzimide compounds inhibit the replication of prototype and pandemic potential poxviruses
by: Jerzy Samolej, et al.
Published: (2024-04-01)

Cloak and Dagger: Alternative Immune Evasion and Modulation Strategies of Poxviruses
by: Susanna R. Bidgood, et al.
Published: (2015-08-01)

Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses
by: Richard B. Kennedy, et al.
Published: (2020-10-01)

Poxvirus-based vector systems and the potential for multi-valent and multi-pathogen vaccines
by: Natalie A. Prow, et al.
Published: (2018-10-01)

Antiviral activity of the EB peptide against zoonotic poxviruses
by: Altmann Sharon E, et al.
Published: (2012-01-01)

Historical Perspectives in the Development of Antiviral Agents Against Poxviruses
by: Erik De Clercq
Published: (2010-06-01)

Tenofovir Activating Kinases May Impact the Outcome of HIV Treatment and Prevention
by: Dimitri Topalis, et al.
Published: (2015-09-01)

Poxvirus Interactions with the Host Ubiquitin System
by: Sian Lant, et al.
Published: (2021-08-01)

Resolution of painful trichodysplasia spinulosa with topical cidofovir: case report
by: Kevin M. Burningham, et al.
Published: (2024-12-01)

Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy
by: Nikolas T. Martin, et al.
Published: (2023-05-01)

Poxvirus Cell Entry: How Many Proteins Does it Take?
by: Bernard Moss
Published: (2012-04-01)

Detection and Molecular Characterization of Zoonotic Poxviruses Circulating in the Amazon Region of Colombia, 2014
by: Jose A. Usme-Ciro, et al.
Published: (2017-04-01)

NK Cells and Poxvirus infection
by: Deborah N. Burshtyn
Published: (2013-01-01)

Intralesional cidofovir for the treatment of recalcitrant periungual warts
by: McKayla Poppens, et al.
Published: (2023-12-01)

A case report of extensive condyloma acuminata in a pediatric patient clearing with compounded 3% cidofovir gel
by: Ben Wroblewski, et al.
Published: (2023-08-01)

Disseminated adenovirus infection twenty-five years post heart-lung transplant complicated by haemophagocytic lymphohistiocytosis
by: Ramu Vathenen, et al.
Published: (2021-07-01)

Battle Royale: Innate Recognition of Poxviruses and Viral Immune Evasion
by: Huibin Yu, et al.
Published: (2021-07-01)

The establishment of a recombinase polymerase amplification technique for the detection of mouse poxvirus
by: Yuexiao Lian, et al.
Published: (2023-12-01)