The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response. Among its effects, FGF21 induces hepatic fatty acid oxidation and ketogenesis, increases insulin sensitivity, blocks somatic growth and causes bone...

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Bibliographic Details
Main Authors: Yuan Zhang, Yang Xie, Eric D Berglund, Katie Colbert Coate, Tian Teng He, Takeshi Katafuchi, Guanghua Xiao, Matthew J Potthoff, Wei Wei, Yihong Wan, Ruth T Yu, Ronald M Evans, Steven A Kliewer, David J Mangelsdorf
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2012-10-01
Series:eLife
Subjects:
longevity
fibroblast growth factor
growth hormone
liver
caloric restriction
Online Access:https://elifesciences.org/articles/00065

Internet

https://elifesciences.org/articles/00065

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