Ethyl Pyruvate Reduces Systemic Leukocyte Activation via Caspase-1 and NF-κB After Blunt Chest Trauma and Haemorrhagic Shock

Ethyl Pyruvate Reduces Systemic Leukocyte Activation via Caspase-1 and NF-κB After Blunt Chest Trauma and Haemorrhagic Shock

Background: Blunt chest (thoracic) trauma (TxT) and haemorrhagic shock with subsequent resuscitation (H/R) induce strong systemic and local inflammatory response, which is closely associated with apoptotic cell loss and subsequently impaired organ function. The underlying mechanisms are not complete...

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Bibliographic Details
Main Authors: Scott Dieteren, Niklas Franz, Kernt Köhler, Aleksander Nowak, Sabrina Ehnert, Alexey Surov, Marcus Krüger, Ingo Marzi, Nils Wagner, Borna Relja
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Medicine
Subjects:
ethyl pyruvate
leukocytes
inflammation
NF-κB
trauma
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.562904/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2020.562904/full

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