Irradiation Suppresses IFNγ-Mediated PD-L1 and MCL1 Expression in EGFR-Positive Lung Cancer to Augment CD8<sup>+</sup> T Cells Cytotoxicity

Irradiation Suppresses IFNγ-Mediated PD-L1 and MCL1 Expression in EGFR-Positive Lung Cancer to Augment CD8<sup>+</sup> T Cells Cytotoxicity

Tumor cells express immune checkpoints to exhaust CD8<sup>+</sup> T cells. Irradiation damages tumor cells and augments tumor immunotherapy in clinical applications. However, the radiotherapy-mediated molecular mechanism affecting CD8<sup>+</sup> T cell activity remains elusi...

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Bibliographic Details
Main Authors: Chun-I. Wang, Yi-Fang Chang, Zong-Lin Sie, Ai-Sheng Ho, Jung-Shan Chang, Cheng-Liang Peng, Chun-Chia Cheng
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
non-small-cell lung cancer
STAT1
STAT3
PD-L1
MCL1
CD8<sup>+</sup> T cells
Online Access:https://www.mdpi.com/2073-4409/10/10/2515

Internet

https://www.mdpi.com/2073-4409/10/10/2515

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